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Abstract
Peronema canescens (Sungkai) has been used in Bengkulu as raw herbal remedy to reduce the fever, some people are using as a malaria drug. P. canescens leaves contain alkaloids, flavonoids, tannins and terpenoids – steroids .This study aims to analyze the effect of P. canescens leaves n-hexane fraction. against paracetemias in Mus musculus infected with Plasmodium berghei, then to prove whether the . P. canescens leaves n-hexane fraction has potential as alternative medicine for malaria . To make P. canescens extract , leaves was macerated using EtOH (96%), then filtrate was evaporated using a rotary evaporator, then fractionated with n-hexane. The 25 healthy M.musculus weighing 20-40g each, infected with P.berghei, grouped into 5 ie group 1 (K-) was treated orally with aquades, group 2 (K +) was treated orally with 0.42 mg of Chloroquine, Group 3 (P1) Group 4 (P2), group 5 (P3) was treated orally with a P. canescens leaves n-hexane fraction each at a dose of 0.028 , 0.056 and 0.084 g / kgBW. After 3 days of digestion for each treatment, the amount of erythrocytes was calculated under a microscope. : The giving of the with dose 0,028 g / kgBW able to inhibit paracetemia 33,49%, 0,056 g / kgBW able to 57.91% and 0,084 g / kgBW able to 61.69% The conclusion is the P. canescens leaves n-hexane fraction at a dose of 0.028 , 0.056 , and 0.084 g / kgBW orally wil be decreased the amount of paracetemia in M.musculus, and the higher the dose given the higher percent of the inhibition.
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References
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- Andriani. Y, 2010, Study Correlation between antioxidant activity and total phenolics content of Phaleria macrocarpa leaves extract, UMTAS International conference, University Malaysia Terengganu (UMT) Kuala Terengganu Malaysia 6-8 Mei
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- Ningsih, A. 2013. Potensi Antimikroba dan Analisis Spektroskopi Isolat Aktif Ekstrak N-Heksan Daun Sungkai (Peronema canescens. Jack) Terhadap Beberapa Mikroba Uji. Molekul11(1):101-111, http://pasca.unhas.ac.id/jurnal/files/pdf (diakses tanggal 23 November 2016)
- Ibrahim, A., dan Hadi Kuncoro. 2012. Identifikasi Metabolit Sekunder dan Aktivitas Antibakteri Ekstrak Daun Sungkai (Peronema canescens Jack) Terhadap Beberapa Bakteri Patogen. Journal Of Tropycal Pharmacy and Chemistry. 2(1).
- Depkes RI. 2008. Pedoman Penatalaksaan Kasus Malaria Di Indonesia. D.J. Pengenda-lian. Jakarta. http://www.depkes.go.id/ download.php?file=download/pusdatin/ buletin/buletin-dbd.pdf
- Darmawan, R. 2014. Uji Aktivitas Antiplas-modium (Peronema canescens) terhadap Mus musculus Jantan Serta Implementasinya seba-gai LKS Pada materi Protista. http://repository.unib.ac.id.
- Badiaraja, P.H.2014. Uji Potensi Antipiretik Daun Muda Sungkai (Peronema canescens) Pada Mus musculus serta Implementasinya dalam pembelajaran sistem Imun di SMA. Skripsi: FKIP UNIB. http://repository.unib. ac.id.
References
Mohamad H , Andriani Y , Bakar K, Siang CC, Syamsumir, DF Alias A and Radzi SAM, S, 2015, Effect of drying method on anti-micro-bial, anti-oxidant activities and isolation of bio-active compounds from Peperomia pellucida (L) Hbk, Journal of Chemical and Pharma-ceutical Research, 7(8). http:// www.jocpr.com.
Andriani Y, 2014, The Miracolous Mahkota Dewa , Article in Voyages of Discovery UMT 2: 9, Publisher : University Malaysia Tereng-ganu, Kuala Terengganu
Andriani. Y, Mohamad, H., 2013, Potential Therapeutic Lead Coumpouds From Our Local Coastal Forest, , The 26th Symposium of Malaysia Analytical Sciences (SKAM 26) , Khuching Serawak Malaysia, 4-5 December.
Andriani. Y, 2010, Study Correlation between antioxidant activity and total phenolics content of Phaleria macrocarpa leaves extract, UMTAS International conference, University Malaysia Terengganu (UMT) Kuala Terengganu Malaysia 6-8 Mei
Yani, A.P. 2013. Kearifan Lokal Penggunaan Tumbuhan Obat Oleh Suku Lembak Delapan di Kabupaten Bengkulu Tengah, Bengkulu http://jurnal.fmipa.unila.ac.id/index.php/ semirata/article/viewFile/575/395.(diakses tanggal 17 November 2016).
Ningsih, A. 2013. Potensi Antimikroba dan Analisis Spektroskopi Isolat Aktif Ekstrak N-Heksan Daun Sungkai (Peronema canescens. Jack) Terhadap Beberapa Mikroba Uji. Molekul11(1):101-111, http://pasca.unhas.ac.id/jurnal/files/pdf (diakses tanggal 23 November 2016)
Ibrahim, A., dan Hadi Kuncoro. 2012. Identifikasi Metabolit Sekunder dan Aktivitas Antibakteri Ekstrak Daun Sungkai (Peronema canescens Jack) Terhadap Beberapa Bakteri Patogen. Journal Of Tropycal Pharmacy and Chemistry. 2(1).
Depkes RI. 2008. Pedoman Penatalaksaan Kasus Malaria Di Indonesia. D.J. Pengenda-lian. Jakarta. http://www.depkes.go.id/ download.php?file=download/pusdatin/ buletin/buletin-dbd.pdf
Darmawan, R. 2014. Uji Aktivitas Antiplas-modium (Peronema canescens) terhadap Mus musculus Jantan Serta Implementasinya seba-gai LKS Pada materi Protista. http://repository.unib.ac.id.
Badiaraja, P.H.2014. Uji Potensi Antipiretik Daun Muda Sungkai (Peronema canescens) Pada Mus musculus serta Implementasinya dalam pembelajaran sistem Imun di SMA. Skripsi: FKIP UNIB. http://repository.unib. ac.id.