Main Article Content


Background: Indonesia ranks fifth in the world with diabetes and diabetes cases are expected to increase continuously. The treatment of diabetes is taking medication and modifying life style. Herbal medicine is used as an additional or substitute drug for diabetes because of its efficacy and has few side effects. Guava leaf is one of the traditional plants that are widely used by the community. Guava leaves have been used as a treatment for diabetes and hypertension in South Africa. Secondary metabolites found in guava leaves such as flavonoids, phenolics and terpenoids were found to have antidiabetic activity. Previous studies have been conducted, but there was no systematic literature review that discussed the efficacy of the antidiabetic effect administration of guava leaves on experimental animals comprehensively.

Methods: This systematic literature review was conducted on three databases, namely Pubmed, Cochrane and Elsevier. Duplicate and irrelevant studies are eliminated, abstracts are screened and followed by reading the entire articles to select journals that fit the inclusion criteria. Critical appraisal uses Joana Brigs Institute tool.

Results:  There were three articles met the criterias. The result of the three studies showed that administration of guava leaf extract is reported able to reduce blood glucose level and improve sensitivity insulin.

Conclusion: Administration of guava leaf extract significantly reduce blood glucose level and improve insulin sensitivity on animal laboratory.


: Guava leaf, blood glucose level, insulin sensitivity, insulin reistant, antidiabetes

Article Details

Author Biography

oktoviani oktoviani, bengkulu university


How to Cite
oktoviani, oktoviani, sania aulia fasa, & ahmad azmi. (2023). EFEK ANTIDIABETES DAUN JAMBU BIJI PADA HEWAN COBA: TINJAUAN KEPUSTAKAAN SISTEMATIS. Jurnal Kedokteran Raflesia, 9(2), 80–88.


  1. Ahamad, A. and Ansari, S.H. (2022) ‘A Review On Multipurpose Medicinal Properties Of Traditionally Used Psidium Guajava Leaves’, Asian Journal of Pharmaceutical and Clinical Research, pp. 9–22. Available at:
  2. Allo, I.G., Wowor, P.M. and Awaloei, H. (2013) ‘Uji Ekstrak Etanol Daun Jambu Biji (Psidium guajava L) Terhadap Kadar Kolesterol Total Tikus Wistar (Rattus norvegicus)’, Jurnal e-Biomedik, 1(1). Available at:
  3. Andriyani, F. and Kurniawati, R. (2020) ‘Manfaat Daun Jambu Biji Untuk Diare’, Jurnal Ilmiah Keperawatan dan Kesehatan Alkautsar (JIKKA), 1(1). Available at: (Accessed: 12 December 2022).
  4. Antara, A.N. (2019) ‘Manfaat Daun Jambu Biji (Psidium guajava) Untuk Kesehatan’, MIKKI (Majalah Ilmu Keperawatan dan Kesehatan Indonesia), 8(2). Available at:
  5. Beidokhti, M.N. et al. (2020) ‘Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production, and triglyceride accumulation in adipocytes’, Journal of Ethnopharmacology, 257, p. 112877. Available at:
  6. Chu, S. et al. (2022) ‘Aqueous Extract of Guava (Psidium guajava L.) Leaf Ameliorates Hyperglycemia by Promoting Hepatic Glycogen Synthesis and Modulating Gut Microbiota’, Frontiers in Pharmacology, 13. Available at: (Accessed: 23 December 2022).
  7. Cyphert, H.A. et al. (2014) ‘Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism’, PLOS ONE, 9(4), p. e94996. Available at:
  8. Darmawan, T.C. (2021) ‘Pengaruh Pemberian Air Rebusan Daun Jambu Biji (Psidium guajava) terhadap Kadar Glukosa Darah Diabetes Mellitus Tipe 1 pada Hewan Mencit (Mus musculus)’, Jurnal Keperawatan, 10(1), pp. 1–8. Available at:
  9. Guo, X. et al. (2013) ‘Guava Leaf Extracts Promote Glucose Metabolism in SHRSP.Z-Leprfa/Izm Rats by Improving Insulin Resistance in Skeletal Muscle’, BMC Complementary and Alternative Medicine, 13, p. 52. Available at:
  10. Guspratiwi, R., Mursyida, E. and Yulinar, Y. (2019) ‘Pengaruh Ekstrak Etanol 96% Daun Jambu Biji (Psidium guajava L.) terhadap Kadar Gula Darah Tikus Wistar Jantan (Rattus novergicus) yang Diinduksi Aloksan’, Collaborative Medical Journal (CMJ), 2(3), pp. 106–116.
  11. Huang, Z. et al. (2021) ‘Bioaccessibility, safety, and antidiabetic effect of phenolic-rich extract from fermented Psidium guajava Linn. leaves’, Journal of Functional Foods, 86, p. 104723. Available at:
  12. IDF (2021) IDF Diabetes Atlas Tenth Edition. Tenth Edition. International Diabetes Federation. Available at: (Accessed: 20 December 2022).
  13. Kumar, M. et al. (2021a) ‘Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities’, Foods, 10(4), p. 752. Available at:
  14. Kumar, M. et al. (2021b) ‘Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities’, Foods, 10(4), p. 752. Available at:
  15. Lankatillake, C., Huynh, T. and Dias, D. (2019) ‘Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants’, Plant Methods [Preprint]. Available at:
  16. Maharani, Rosalina and Purwaningsih, P. (2013) ‘Pengaruh Pemberian Air Rebusan Daun Jambu Biji (Psidium guajava) Terhadap Kadar Glukosa Darah pada Penderita Diabetes Mellitus Tipe II Di Desa Leyangan Kecamatan Unggaran Timur Kabupaten Semarang’, Jurnal Keperawatan Medikal Bedah, 1(2). Available at: (Accessed: 5 December 2022).
  17. Mathur, R. et al. (2015) ‘Psidium Guajava Linn. Leaf Extract Affects Hepatic Glucose Transporter-2 to Attenuate Early Onset of Insulin Resistance Consequent to High Fructose Intake: An Experimental Study’, Pharmacognosy Research, 7(2), pp. 166–175. Available at:
  18. Mazumdar, S., Akter, R. and Talukder, D. (2015) ‘Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava (L.) Bat. leaves in Wister rats’, Asian Pacific Journal of Tropical Biomedicine, 5(1), pp. 10–14. Available at:
  19. Perkumpulan Endokrinologi Indonesia (2021) ‘Pedoman Pengelolaan dan Pencegahan Diabetes Mellitus Tipe 2 Dewasa di Indonesia’, PB PERKENI [Preprint].
  20. Rambe, Y. et al. (2022) ‘Pengolahan Tanaman Daun Jambu Biji Menjadi Obat Herbal’, 1(2), p. 4.
  21. Rehman, S.U. et al. (2015) ‘Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management’, Archives of Pharmacal Research, 38(7), pp. 1281–1298. Available at:
  22. Sapra, A. and Bhandari, P. (2022) ‘Diabetes Mellitus’, in StatPearls. Treasure Island (FL): StatPearls Publishing. Available at: (Accessed: 20 December 2022).
  23. Xu, C. et al. (2020) ‘Amino Acid Profiling Study of Psidium guajava L. Leaves as an Effective Treatment for Type 2 Diabetic Rats’, Evidence-based Complementary and Alternative Medicine : eCAM, 2020, p. 9784382. Available at:
  24. Yang, Q. et al. (2020) ‘Guava Leaf Extract Attenuates Insulin Resistance via the PI3K/Akt Signaling Pathway in a Type 2 Diabetic Mouse Model’, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, pp. 713–718. Available at:
  25. Yu, S. et al. (2021) ‘Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis’, Molecular Metabolism, 53, p. 101257. Available at: