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Abstrak
Dengue fever is a disease caused by the dengue virus (DENV) which often becomes a problem for public health in the world with approximately 390 million cases of infection. The lack of specific antiviral therapy for DENV is a driving force for the development of a dengue vaccine as a strategy to fight the DENV virus. This review discusses the development of dengue vaccines and makes effectivity comparisons with dengue vaccines that have been developed such as Dengvaxia, TV003/TV005, and DENVax to know the current status of the development of these vaccines.
Keywords : Dengue fever, Dengue Virus, vaccines, development, effectivity
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Hak Cipta (c) 2024 Tisa Aulia

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Referensi
- Abbas, A. K., Lichtman, A. H., & Pillai, S. (2012). Cellular and Molecular Immunology (7th ed.). Elsevier
- Saunders.
- Akter, R., Tasneem, F., Das, S., Soma, M. A., Georgakopoulos-Soares, I., Juthi, R. T., & Sazed, S. A.
- (2024). Approaches of dengue control: vaccine strategies and future aspects. In Frontiers in
- Immunology (Vol. 15). Frontiers Media SA. https://doi.org/10.3389/fimmu.2024.1362780
- Foucambert, P., Esbrand, F. D., Zafar, S., Panthangi, V., Cyril Kurupp, A. R., Raju, A., Luthra, G.,
- Shahbaz, M., Almatooq, H., & Khan, S. (2022). Efficacy of Dengue Vaccines in the Prevention of
- Severe Dengue in Children: A Systematic Review. Cureus, 14(9), e28916.
- https://doi.org/10.7759/cureus.28916
- Harapan, H., Michie, A., Sasmono, R. T., & Imrie, A. (2020). Dengue: A Minireview. Viruses, 12(8).
- https://doi.org/10.3390/v12080829
- Khetarpal, N., & Khanna, I. (2016). Dengue Fever: Causes, Complications, and Vaccine Strategies.
- Journal of Immunology Research, 2016, 1–14. https://doi.org/10.1155/2016/6803098
- Kuhn, R. J., Zhang, W., Rossmann, M. G., Pletnev, S. V, Corver, J., Lenches, E., Jones, C. T.,
- Mukhopadhyay, S., Chipman, P. R., Strauss, E. G., Baker, T. S., & Strauss, J. H. (2002). Structure
- of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell, 108(5), 717–
- https://doi.org/10.1016/s0092-8674(02)00660-8
- Laydon, D. J., Dorigatti, I., Hinsley, W. R., Nedjati-Gilani, G., Coudeville, L., & Ferguson, N. M. (2021).
- Efficacy profile of the CYD-TDV dengue vaccine revealed by Bayesian survival analysis of
- individual-level phase III data. ELife, 10. https://doi.org/10.7554/eLife.65131
- Ma, E., & Cheng, G. (2022). Host immunity and vaccine development against Dengue virus. Infectious
- Medicine, 1(1), 50–58. https://doi.org/10.1016/j.imj.2021.12.003
- Marimuthu, P., & Ravinder, J. R. (2016). Trends in clinical trials of dengue vaccine. Perspectives in
- Clinical Research, 7(4), 161–164. https://doi.org/10.4103/2229-3485.192035
- Murugesan, A., & Manoharan, M. (2020). Dengue Virus. In Emerging and Reemerging Viral Pathogens
- (pp. 281–359). Elsevier. https://doi.org/10.1016/B978-0-12-819400-3.00016-8
- Nanaware, N., Banerjee, A., Mullick Bagchi, S., Bagchi, P., & Mukherjee, A. (2021). Dengue Virus
- Infection: A Tale of Viral Exploitations and Host Responses. Viruses, 13(10).
- https://doi.org/10.3390/v13101967
- Nugraheni, E., Rizqoh, D., & Sundari, M. (2023). Manifestasi Klinis Demam Berdarah Dengue (DBD).
- Jurnal Kedokteran Dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya,
- (3), 267–274. https://doi.org/10.32539/jkk.v10i3.21425
- Thomas, S. J., & Yoon, I. K. (2019). A review of Dengvaxia®: development to deployment. Human
- Vaccines and Immunotherapeutics, 15(10), 2295–2314.
- https://doi.org/10.1080/21645515.2019.1658503
- Wilder-Smith, A. (2022). Dengue vaccine development: challenges and prospects. Current Opinion in
- Infectious Diseases, 35(5), 390–396. https://doi.org/10.1097/QCO.0000000000000871
Referensi
Abbas, A. K., Lichtman, A. H., & Pillai, S. (2012). Cellular and Molecular Immunology (7th ed.). Elsevier
Saunders.
Akter, R., Tasneem, F., Das, S., Soma, M. A., Georgakopoulos-Soares, I., Juthi, R. T., & Sazed, S. A.
(2024). Approaches of dengue control: vaccine strategies and future aspects. In Frontiers in
Immunology (Vol. 15). Frontiers Media SA. https://doi.org/10.3389/fimmu.2024.1362780
Foucambert, P., Esbrand, F. D., Zafar, S., Panthangi, V., Cyril Kurupp, A. R., Raju, A., Luthra, G.,
Shahbaz, M., Almatooq, H., & Khan, S. (2022). Efficacy of Dengue Vaccines in the Prevention of
Severe Dengue in Children: A Systematic Review. Cureus, 14(9), e28916.
https://doi.org/10.7759/cureus.28916
Harapan, H., Michie, A., Sasmono, R. T., & Imrie, A. (2020). Dengue: A Minireview. Viruses, 12(8).
https://doi.org/10.3390/v12080829
Khetarpal, N., & Khanna, I. (2016). Dengue Fever: Causes, Complications, and Vaccine Strategies.
Journal of Immunology Research, 2016, 1–14. https://doi.org/10.1155/2016/6803098
Kuhn, R. J., Zhang, W., Rossmann, M. G., Pletnev, S. V, Corver, J., Lenches, E., Jones, C. T.,
Mukhopadhyay, S., Chipman, P. R., Strauss, E. G., Baker, T. S., & Strauss, J. H. (2002). Structure
of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell, 108(5), 717–
https://doi.org/10.1016/s0092-8674(02)00660-8
Laydon, D. J., Dorigatti, I., Hinsley, W. R., Nedjati-Gilani, G., Coudeville, L., & Ferguson, N. M. (2021).
Efficacy profile of the CYD-TDV dengue vaccine revealed by Bayesian survival analysis of
individual-level phase III data. ELife, 10. https://doi.org/10.7554/eLife.65131
Ma, E., & Cheng, G. (2022). Host immunity and vaccine development against Dengue virus. Infectious
Medicine, 1(1), 50–58. https://doi.org/10.1016/j.imj.2021.12.003
Marimuthu, P., & Ravinder, J. R. (2016). Trends in clinical trials of dengue vaccine. Perspectives in
Clinical Research, 7(4), 161–164. https://doi.org/10.4103/2229-3485.192035
Murugesan, A., & Manoharan, M. (2020). Dengue Virus. In Emerging and Reemerging Viral Pathogens
(pp. 281–359). Elsevier. https://doi.org/10.1016/B978-0-12-819400-3.00016-8
Nanaware, N., Banerjee, A., Mullick Bagchi, S., Bagchi, P., & Mukherjee, A. (2021). Dengue Virus
Infection: A Tale of Viral Exploitations and Host Responses. Viruses, 13(10).
https://doi.org/10.3390/v13101967
Nugraheni, E., Rizqoh, D., & Sundari, M. (2023). Manifestasi Klinis Demam Berdarah Dengue (DBD).
Jurnal Kedokteran Dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya,
(3), 267–274. https://doi.org/10.32539/jkk.v10i3.21425
Thomas, S. J., & Yoon, I. K. (2019). A review of Dengvaxia®: development to deployment. Human
Vaccines and Immunotherapeutics, 15(10), 2295–2314.
https://doi.org/10.1080/21645515.2019.1658503
Wilder-Smith, A. (2022). Dengue vaccine development: challenges and prospects. Current Opinion in
Infectious Diseases, 35(5), 390–396. https://doi.org/10.1097/QCO.0000000000000871