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Abstrak
Penyakit tuberkulosis disebabkan oleh bakteri Mycobacterium tuberculosis yang menyerang organ tubuh manusia. Tujuan dari penelitian ini adalah untuk menemukan senyawa dari tanaman Eukaliptus lemon, yaitu Linalool, Isopulegol, Farnesan, dan Citronellol yang paling berpotensi sebagai obat tuberculosis melalui metode molecular docking. Pada penelitian ini digunakan 2 jenis protein yaitu 4KM2 dan 4KL9 yang ditambatkan dengan senyawa Eukaliptus lemon. Hasil docking dievaluasi berdasarkan parameter dari nilai konstanta inhibisi (ki) dan nilai energi afinitas (ΔG). Senyawa Farnesan menunjukkan hasil terbaik dengan energi afinitas (ΔG) terendah, yaitu 5,3 kcal/mol, dan ki sebesar 0,9144 µM. Hasil ini menunjukan Farnesan memiliki potensi sebagai kandidat resistensi obat untuk menyembuhkan penyakit tuberculosis.
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Hak Cipta (c) 2024 Fiona Fiona, Jesi Pebralia, S.Pd., M.Si., Tika Restianingsih, Frincess Yeny Sirait, Irene Regina
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Jesi Pebralia, Program Studi Fisika, Fakultas Sains dan Teknologi, Universitas Jambi, Indonesia
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Referensi
- E. Kenedyanti and L. Sulistyorini, “Analisis Mycobacterium Tuberculosis Dan Kondisi Fisik Rumah Dengan Kejadian Tuberkulosis Paru,” J. Berk. Epidemiol., vol. 5, no. 2, pp. 152–162, 2017, doi: 10.20473/jbe.v5i2.2017.152-162.
- M. F. Alfathin, D. Herawati, and T. M. Faqih, “Studi In Silico Senyawa Turunan Ftalosianin terhadap Reseptor InhA pada Mycobacterium tuberculosis sebagai Kandidat Senyawa Photosensitizer,” Pros. Farm., vol. 7, no. 2, pp. 284–291, 2021, [Online]. Available: http://dx.doi.org/10.29313/.v0i0.28107.
- Y. Faturrahman, A. Setiyono, and R. S. A, “Analisis faktor risiko kejadian tuberkulosis di wilayah puskemas Kelurahan Cipinang Besar Utara Kota Administrasi Jakarta Timur,” J. Kesehat. komunitas Indones., vol. 17, no. 2, pp. 346–354, 2021.
- R. Ruswanto, M. Mardhiah, R. Mardianingrum, and K. Novitriani, “Sintesis Dan Studi in Silico Senyawa 3-Nitro-N’-[(Pyridin-4-Yl) Carbonyl]Benzohydrazide Sebagai Kandidat Antituberkulosis,” Chim. Nat. Acta, vol. 3, no. 2, 2015, doi: 10.24198/cna.v3.n2.9183.
- M. Halim, “Kepatuhan Pasien Rawat Jalan Poli Paru Dalam Penggunaan Obat Anti Tuberkulosis (Oat) Di Rumah Sakit Kartika Husada Jatiasih Bekasi,” J. Farm. IKIFA, vol. 2, no. 1, pp. 30–37, 2023.
- R. F. Ramos Alvarenga, B. Wan, T. Inui, S. G. Franzblau, G. F. Pauli, and B. U. Jaki, “Airborne antituberculosis activity of Eucalyptus citriodora essential oil,” J. Nat. Prod., vol. 77, no. 3, pp. 603–610, 2014, doi: 10.1021/np400872m.
- J. U. Ewansiha, A. J. Adeleke, L. S. Orji, and I. D. Kolawole, Therapeutic Potency of Lemon-Scented Gum (Eucalyptus Citriodora) Leaf Extract for the Development of Antibacterial Drug, vol. 37, no. 3. 2022.
- S. Mulyaningsih, F. Sporer, J. Reichling, and M. Wink, “Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens,” Pharm. Biol., vol. 49, no. 9, pp. 893–899, 2011, doi: 10.3109/13880209.2011.553625.
- S. H. Al-Mijalli et al., “Combination of sweet orange, lentisk and lemon eucalyptus essential oils: Optimization of a new complete antimicrobial formulation using a mixture design methodology,” Heliyon, vol. 9, no. 9, p. e19814, 2023, doi: 10.1016/j.heliyon.2023.e19814.
- D. S. R. Koresy and A. Jayuska, “Isolasi dan Aktivitas Antibakteri Minyak Atsiri Daun Gugur Eucalyptus staigeriana,” J. Kim. Khatulistiwa, vol. 8, no. 1, pp. 91–95, 2019.
- S. Das, “Herbal Anti-Tuberculosis Medicaments: Highlighting New Advances in Therapeutics,” Int. J. Med. Pharm. Sci., vol. 11, no. 02, 2021, doi: 10.31782/ijmps.2021.11201.
- N. C. Endriyatno and M. Walid, “Studi In Silico Kandungan Senyawa Daun Srikaya (Annona squamosa L.)Terhadap Protein Dihydrofolate Reductase Pada Mycobacterium tuberculosis,” Pharmacon J. Farm. Indones., vol. 19, no. 1, pp. 87–98, 2022, doi: 10.23917/pharmacon.v19i1.18044.
- I. Irwan, Hajrah, and Y. Sastyarina, “Simulasi Docking Senyawa Napthoquinones Umbi Bawang Tiwai (Eleutherine americana Merr.) terhadap Bakteri Mycobacterium tuberculosis Docking,” J. Proceeding Mulawarman Pharm. Conf., vol. 1, no. April 2021, pp. 135–138, 2021, [Online]. Available: http://prosiding.farmasi.unmul.ac.id/index.php/mpc/article/view/416/399.
- H. Lailiyyah and L. Lisdiana, “Uji Aktivitas Antibakteri Senyawa Aktif Temu Kunci ( Boesenbergia rotunda ) terhadap Mycobacterium tuberculosis secara In Silico Antibacterial Activity of Temu Kunci ( Boesenbergia rotunda ) Active Compounds to Mycobacterium tuberculosis In Silico,” vol. 12, pp. 132–149, 2023.
Referensi
E. Kenedyanti and L. Sulistyorini, “Analisis Mycobacterium Tuberculosis Dan Kondisi Fisik Rumah Dengan Kejadian Tuberkulosis Paru,” J. Berk. Epidemiol., vol. 5, no. 2, pp. 152–162, 2017, doi: 10.20473/jbe.v5i2.2017.152-162.
M. F. Alfathin, D. Herawati, and T. M. Faqih, “Studi In Silico Senyawa Turunan Ftalosianin terhadap Reseptor InhA pada Mycobacterium tuberculosis sebagai Kandidat Senyawa Photosensitizer,” Pros. Farm., vol. 7, no. 2, pp. 284–291, 2021, [Online]. Available: http://dx.doi.org/10.29313/.v0i0.28107.
Y. Faturrahman, A. Setiyono, and R. S. A, “Analisis faktor risiko kejadian tuberkulosis di wilayah puskemas Kelurahan Cipinang Besar Utara Kota Administrasi Jakarta Timur,” J. Kesehat. komunitas Indones., vol. 17, no. 2, pp. 346–354, 2021.
R. Ruswanto, M. Mardhiah, R. Mardianingrum, and K. Novitriani, “Sintesis Dan Studi in Silico Senyawa 3-Nitro-N’-[(Pyridin-4-Yl) Carbonyl]Benzohydrazide Sebagai Kandidat Antituberkulosis,” Chim. Nat. Acta, vol. 3, no. 2, 2015, doi: 10.24198/cna.v3.n2.9183.
M. Halim, “Kepatuhan Pasien Rawat Jalan Poli Paru Dalam Penggunaan Obat Anti Tuberkulosis (Oat) Di Rumah Sakit Kartika Husada Jatiasih Bekasi,” J. Farm. IKIFA, vol. 2, no. 1, pp. 30–37, 2023.
R. F. Ramos Alvarenga, B. Wan, T. Inui, S. G. Franzblau, G. F. Pauli, and B. U. Jaki, “Airborne antituberculosis activity of Eucalyptus citriodora essential oil,” J. Nat. Prod., vol. 77, no. 3, pp. 603–610, 2014, doi: 10.1021/np400872m.
J. U. Ewansiha, A. J. Adeleke, L. S. Orji, and I. D. Kolawole, Therapeutic Potency of Lemon-Scented Gum (Eucalyptus Citriodora) Leaf Extract for the Development of Antibacterial Drug, vol. 37, no. 3. 2022.
S. Mulyaningsih, F. Sporer, J. Reichling, and M. Wink, “Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens,” Pharm. Biol., vol. 49, no. 9, pp. 893–899, 2011, doi: 10.3109/13880209.2011.553625.
S. H. Al-Mijalli et al., “Combination of sweet orange, lentisk and lemon eucalyptus essential oils: Optimization of a new complete antimicrobial formulation using a mixture design methodology,” Heliyon, vol. 9, no. 9, p. e19814, 2023, doi: 10.1016/j.heliyon.2023.e19814.
D. S. R. Koresy and A. Jayuska, “Isolasi dan Aktivitas Antibakteri Minyak Atsiri Daun Gugur Eucalyptus staigeriana,” J. Kim. Khatulistiwa, vol. 8, no. 1, pp. 91–95, 2019.
S. Das, “Herbal Anti-Tuberculosis Medicaments: Highlighting New Advances in Therapeutics,” Int. J. Med. Pharm. Sci., vol. 11, no. 02, 2021, doi: 10.31782/ijmps.2021.11201.
N. C. Endriyatno and M. Walid, “Studi In Silico Kandungan Senyawa Daun Srikaya (Annona squamosa L.)Terhadap Protein Dihydrofolate Reductase Pada Mycobacterium tuberculosis,” Pharmacon J. Farm. Indones., vol. 19, no. 1, pp. 87–98, 2022, doi: 10.23917/pharmacon.v19i1.18044.
I. Irwan, Hajrah, and Y. Sastyarina, “Simulasi Docking Senyawa Napthoquinones Umbi Bawang Tiwai (Eleutherine americana Merr.) terhadap Bakteri Mycobacterium tuberculosis Docking,” J. Proceeding Mulawarman Pharm. Conf., vol. 1, no. April 2021, pp. 135–138, 2021, [Online]. Available: http://prosiding.farmasi.unmul.ac.id/index.php/mpc/article/view/416/399.
H. Lailiyyah and L. Lisdiana, “Uji Aktivitas Antibakteri Senyawa Aktif Temu Kunci ( Boesenbergia rotunda ) terhadap Mycobacterium tuberculosis secara In Silico Antibacterial Activity of Temu Kunci ( Boesenbergia rotunda ) Active Compounds to Mycobacterium tuberculosis In Silico,” vol. 12, pp. 132–149, 2023.