Main Article Content
Abstract
Di era sekarang, pola hidup sehat makin digemari dibarengi dengan makin tercemarnya lingkungan. Kesadaran akan makanan yang aman untuk dikonsumsi semakin meningkat. Pencemaran pada lingkungan berdampak pada tercemarnya bahan makanan. Metal-organic frameworks (MOFs) adalah material baru yang memiliki banyak potensi aplikasi, salah satunya adalah untuk analisis makanan. MOF memiliki karakteristik yang unik, seperti pori-pori yang besar dan luas permukaan yang tinggi, yang membuatnya cocok untuk digunakan dalam proses ekstraksi, Metode magnetic solid phase extraction (MSPE) adalah metode ekstraksi yang menggunakan material magnetik untuk menyerap dan mengumpulkan analit dari larutan. Metode ini memiliki beberapa keunggulan, seperti efisiensi ekstraksi yang tinggi, kemudahan pemisahan analit dari material magnetik, dan biaya yang relatif rendah. Pada review kali ini, akan dibahas mengenai cara kerja metode MSPE, perbandingan MOFs yang digunakan pada bermacam sampel berdasarkan penelitian; dan MOFs yang terbaik yang dapat digunakan untuk mendeteksi dan menghilangkan kontaminan yang ada pada makanan.
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Copyright (c) 2024 Aditya Ramadhani, Esra Noviyanti Br. Karo, Ester Damayanti Manik, Mauliyani, Marvin Horale Pasaribu

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Isian pada kolom ini dibuat oto matis saat Anda memilih salah satu dari kolom “Copyright Hol der”.References
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- kabupaten brebes. Jurnal Visikes. 2011;10(1):69-75.
- . Habibah N, Dhyanaputri IG, Karta IW, Dewi NN. Analisis Kuantitatif Kadar Nitrit
- dalam Produk Daging Olahan di Wilayah Denpasar Dengan Metode Griess Secara
- Spektrofotometri. International Journal of Natural Science and Engineering. 2018
- Apr 18;2(1):1-9.
- . Bradshaw D, Garai A, Huo J. Metal–organic framework growth at functional
- interfaces: thin films and composites for diverse applications. Chemical Society
- Reviews. 2012;41(6):2344-81.
- . Pasaribu MH, Karelius K, Ramdhani EP, Agnestisia R, Pereiz Z, Toepak EP. Synthesis
- of Mil-100 (Fe)@ Fe3O4 Composite using Zircon Mining Magnetic Waste as an
- Adsorbent for Methylene Blue Dye. InBIO Web of Conferences. 2023 (Vol. 70, p.
- . EDP Sciences.
- . Rocío-Bautista P, Pino V, Ayala JH, Pasán J, Ruiz-Pérez C, Afonso AM. A magneticbased
- dispersive micro-solid-phase extraction method using the metal-organic
- framework HKUST-1 and ultra-high-performance liquid chromatography with
- fluorescence detection for determining polycyclic aromatic hydrocarbons in waters
- and fruit tea infusions. Journal of Chromatography A. 2016 Mar 4;1436:42-50.
- . Zhou Z, Fu Y, Qin Q, Lu X, Shi X, Zhao C, Xu G. Synthesis of magnetic mesoporous
- metal-organic framework-5 for the effective enrichment of malachite green and
- crystal violet in fish samples. Journal of Chromatography A. 2018 ;1560:19-25.
- . Vatta LL, Sanderson RD, Koch KR. Magnetic nanoparticles: Properties and potential
- applications. Pure and applied chemistry. 2006 ;78(9):1793-801.
- . Hu Y, Lian H, Zhou L, Li G. In situ solvothermal growth of metal–organic framework-5
- supported on porous copper foam for noninvasive sampling of plant volatile sulfides.
- Analytical chemistry. 2015 ;87(1):406-12.
- . Herrero-Latorre C, Barciela-García J, García-Martín S, Peña-Crecente RM, Otárola-
- Jiménez J. Magnetic solid-phase extraction using carbon nanotubes as sorbents: A
- review. Analytica Chimica Acta. 2015 ;892:10-26.
- .Płotka-Wasylka J, Szczepańska N, de La Guardia M, Namieśnik J. Miniaturized solidphase
- extraction techniques. TrAC Trends in Analytical Chemistry. 2015 ;73:19-38.
- .Wierucka M, Biziuk M. Application of magnetic nanoparticles for magnetic solidphase
- extraction in preparing biological, environmental and food samples. TrAC
- Trends in Analytical Chemistry. 2014 ;59:50-8.
- .Shi XR, Chen XL, Hao YL, Li L, Xu HJ, Wang MM. Magnetic metal-organic frameworks
- for fast and efficient solid-phase extraction of six Sudan dyes in tomato sauce.
- Journal of Chromatography B. 2018 ;1086:146-52.
- .Huang C, Qiao X, Sun W, Chen H, Chen X, Zhang L, Wang T. Effective extraction of
- domoic acid from seafood based on postsynthetic-modified magnetic zeolite
- imidazolate framework-8 particles. Analytical chemistry. 2019 Jan 4;91(3):2418-24.
- .Wang X, Wang S, Cai Z. The latest developments and applications of mass
- spectrometry in food-safety and quality analysis. TrAC Trends in Analytical
- Chemistry. 2013 ;52:170–85.
- .Magri A, Petriccione M, Gutiérrez TJ. Metal-organic frameworks for food applications:
- A review. Food Chemistry. 2021 ;354:129533.
- .Han S, Wei Y, Valente C, Lagzi I, Gassensmith JJ, Coskun A, Stoddart JF, Grzybowski
- BA. Chromatography in a single metal− organic framework (MOF) crystal. Journal of
- the American Chemical Society. 2010 ;132(46):16358-61.
- .Wang PL, Xie LH, Joseph EA, Li JR, Su XO, Zhou HC. Metal–organic frameworks for
- food safety. Chemical reviews. 2019 ;119(18):10638-90.
- .Hu Y, Huang Z, Liao J, Li G. Chemical bonding approach for fabrication of hybrid
- magnetic metal–organic framework-5: high efficient adsorbents for magnetic
- enrichment of trace analytes. Analytical chemistry. 2013 ;85(14):6885-93.
- .Taghizadeh, M., Asgharinezhad, A.A., Pooladi, M., Barzin, M., Abbaszadeh, A. and
- Tadjarodi, A. A novel magnetic metal organic framework nanocomposite for
- extraction and preconcentration of heavy metal ions, and its optimization via
- experimental design methodology. Microchimica Acta, 2013. 180, pp.1073-1084.
- .Lan H, Gan N, Pan D, Hu F, Li T, Long N, Shen H, Feng Y. Development of a novel
- magnetic molecularly imprinted polymer coating using porous zeolite imidazolate
- framework-8 coated magnetic iron oxide as carrier for automated solid phase
- microextraction of estrogens in fish and pork samples. Journal of Chromatography A.
- ;1365:35-44.
- .Sohrabi MR, Matbouie Z, Asgharinezhad AA, Dehghani A. Solid phase extraction of
- Cd(II) and Pb(II) using a magnetic metal-organic framework, and their
- determination by FAAS. Microchimica Acta. 2013;180(7–8):589–97.
- .Xia L, Liu L, Lv X, Qu F, Li G, You J. Towards the determination of sulfonamides in
- meat samples: A magnetic and mesoporous metal-organic framework as an efficient
- sorbent for magnetic solid phase extraction combined with high-performance liquid
- chromatography. Journal of Chromatography A. 2017;1500:24-31.
- .Li Z, Qi M, Tu C, Wang W, Chen J, Wang AJ. Magnetic Metal-Organic
- Framework/Graphene Oxide-Based Solid-Phase Extraction Combined with
- Spectrofluorimetry for the Determination of Enrofloxacin in Milk Sample. Food Anal
- Methods. 2017;10(12):4094–103.
- .Su H, Lin Y, Wang Z, Wong YLE, Chen X, Chan TWD. Magnetic metal–organic
- framework–titanium dioxide nanocomposite as adsorbent in the magnetic solidphase
- extraction of fungicides from environmental water samples. Journal of
- Chromatography A. 2016;1466:21–8.
- .Zhou Q, Lei M, Li J, Liu Y, Zhao K, Zhao D. Magnetic solid phase extraction of N- and
- S-containing polycyclic aromatic hydrocarbons at ppb levels by using a zerovalent
- iron nanoscale material modified with a metal organic framework of type Fe@MOF-
- , and their determination by HPLC. Microchimica Acta. 2017;184(4):1029–36.
- .Chen X, Ding N, Zang H, Yeung H, Zhao RS, Cheng C, dkk. Fe3O4@MOF core–shell
- magnetic microspheres for magnetic solid-phase extraction of polychlorinated
- biphenyls from environmental water samples. Journal of Chromatography A.
- ;1304:241–5.
- .Liu Y, Gao Z, Wu R, Wang Z, Chen X, Chan TWD. Magnetic porous carbon derived
- from a bimetallic metal–organic framework for magnetic solid-phase extraction of
- organochlorine pesticides from drinking and environmental water samples. Journal
- of Chromatography A. 2017;1479:55–61.
- .Liang L, Wang X, Sun Y, Ma P, Li X, Piao H, dkk. Magnetic solid-phase extraction of
- triazine herbicides from rice using metal-organic framework MIL-101(Cr)
- functionalized magnetic particles. Talanta. 2018;179:512–9.
- .Hassanpour A, Hosseinzadeh-Khanmiri R, Babazadeh M, Abolhasani J, Ghorbani-
- Kalhor E. Determination of heavy metal ions in vegetable samples using a magnetic
- metal–organic framework nanocomposite sorbent. Food Additives & Contaminants:
- Part A. 2015 ;32(5):725-36.
- .Wang Y, Chen H, Tang J, Ye G, Ge H, Hu X. Preparation of magnetic metal organic
- frameworks adsorbent modified with mercapto groups for the extraction and
- analysis of lead in food samples by flame atomic absorption spectrometry. Food
- Chemistry. 2015 ;181:191-7.
- .Rocío-Bautista P, Pino V, Ayala JH, Pasán J, Ruiz-Pérez C, Afonso AM. A magneticbased
- dispersive micro-solid-phase extraction method using the metal-organic
- framework HKUST-1 and ultra-high-performance liquid chromatography with
- fluorescence detection for determining polycyclic aromatic hydrocarbons in waters
- and fruit tea infusions. Journal of Chromatography A. 2016;1436:42–50.
- .Ghorbani-Kalhor E, Hosseinzadeh-Khanmiri R, Babazadeh M, Abolhasani J,
- Hassanpour A. Synthesis and application of a novel magnetic metal-organic
- framework nanocomposite for determination of Cd, Pb, and Zn in baby food samples.
- Canadian Journal of Chemistry. 2015;93(5):518-25..
- .Ma J, Yao Z, Hou L, Lu W, Yang Q, Li J, dkk. Metal organic frameworks (MOFs) for
- magnetic solid-phase extraction of pyrazole/pyrrole pesticides in environmental
- water samples followed by HPLC-DAD determination. Talanta. 2016;161:686–92.
- .Lu N, He X, Wang T, Liu S, Hou X. Magnetic solid-phase extraction using MIL-
- (Cr)-based composite combined with dispersive liquid-liquid microextraction
- based on solidification of a floating organic droplet for the determination of
- pyrethroids in environmental water and tea samples. Microchemical Journal.
- ;137:449–55.
- .Hao L, Wang C, Wu Q, Li Z, Zang X, Wang Z. Metal–organic framework derived
- magnetic nanoporous carbon: novel adsorbent for magnetic solid-phase extraction.
- Analytical chemistry. 2014;86(24):12199-205.
References
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kabupaten brebes. Jurnal Visikes. 2011;10(1):69-75.
. Habibah N, Dhyanaputri IG, Karta IW, Dewi NN. Analisis Kuantitatif Kadar Nitrit
dalam Produk Daging Olahan di Wilayah Denpasar Dengan Metode Griess Secara
Spektrofotometri. International Journal of Natural Science and Engineering. 2018
Apr 18;2(1):1-9.
. Bradshaw D, Garai A, Huo J. Metal–organic framework growth at functional
interfaces: thin films and composites for diverse applications. Chemical Society
Reviews. 2012;41(6):2344-81.
. Pasaribu MH, Karelius K, Ramdhani EP, Agnestisia R, Pereiz Z, Toepak EP. Synthesis
of Mil-100 (Fe)@ Fe3O4 Composite using Zircon Mining Magnetic Waste as an
Adsorbent for Methylene Blue Dye. InBIO Web of Conferences. 2023 (Vol. 70, p.
. EDP Sciences.
. Rocío-Bautista P, Pino V, Ayala JH, Pasán J, Ruiz-Pérez C, Afonso AM. A magneticbased
dispersive micro-solid-phase extraction method using the metal-organic
framework HKUST-1 and ultra-high-performance liquid chromatography with
fluorescence detection for determining polycyclic aromatic hydrocarbons in waters
and fruit tea infusions. Journal of Chromatography A. 2016 Mar 4;1436:42-50.
. Zhou Z, Fu Y, Qin Q, Lu X, Shi X, Zhao C, Xu G. Synthesis of magnetic mesoporous
metal-organic framework-5 for the effective enrichment of malachite green and
crystal violet in fish samples. Journal of Chromatography A. 2018 ;1560:19-25.
. Vatta LL, Sanderson RD, Koch KR. Magnetic nanoparticles: Properties and potential
applications. Pure and applied chemistry. 2006 ;78(9):1793-801.
. Hu Y, Lian H, Zhou L, Li G. In situ solvothermal growth of metal–organic framework-5
supported on porous copper foam for noninvasive sampling of plant volatile sulfides.
Analytical chemistry. 2015 ;87(1):406-12.
. Herrero-Latorre C, Barciela-García J, García-Martín S, Peña-Crecente RM, Otárola-
Jiménez J. Magnetic solid-phase extraction using carbon nanotubes as sorbents: A
review. Analytica Chimica Acta. 2015 ;892:10-26.
.Płotka-Wasylka J, Szczepańska N, de La Guardia M, Namieśnik J. Miniaturized solidphase
extraction techniques. TrAC Trends in Analytical Chemistry. 2015 ;73:19-38.
.Wierucka M, Biziuk M. Application of magnetic nanoparticles for magnetic solidphase
extraction in preparing biological, environmental and food samples. TrAC
Trends in Analytical Chemistry. 2014 ;59:50-8.
.Shi XR, Chen XL, Hao YL, Li L, Xu HJ, Wang MM. Magnetic metal-organic frameworks
for fast and efficient solid-phase extraction of six Sudan dyes in tomato sauce.
Journal of Chromatography B. 2018 ;1086:146-52.
.Huang C, Qiao X, Sun W, Chen H, Chen X, Zhang L, Wang T. Effective extraction of
domoic acid from seafood based on postsynthetic-modified magnetic zeolite
imidazolate framework-8 particles. Analytical chemistry. 2019 Jan 4;91(3):2418-24.
.Wang X, Wang S, Cai Z. The latest developments and applications of mass
spectrometry in food-safety and quality analysis. TrAC Trends in Analytical
Chemistry. 2013 ;52:170–85.
.Magri A, Petriccione M, Gutiérrez TJ. Metal-organic frameworks for food applications:
A review. Food Chemistry. 2021 ;354:129533.
.Han S, Wei Y, Valente C, Lagzi I, Gassensmith JJ, Coskun A, Stoddart JF, Grzybowski
BA. Chromatography in a single metal− organic framework (MOF) crystal. Journal of
the American Chemical Society. 2010 ;132(46):16358-61.
.Wang PL, Xie LH, Joseph EA, Li JR, Su XO, Zhou HC. Metal–organic frameworks for
food safety. Chemical reviews. 2019 ;119(18):10638-90.
.Hu Y, Huang Z, Liao J, Li G. Chemical bonding approach for fabrication of hybrid
magnetic metal–organic framework-5: high efficient adsorbents for magnetic
enrichment of trace analytes. Analytical chemistry. 2013 ;85(14):6885-93.
.Taghizadeh, M., Asgharinezhad, A.A., Pooladi, M., Barzin, M., Abbaszadeh, A. and
Tadjarodi, A. A novel magnetic metal organic framework nanocomposite for
extraction and preconcentration of heavy metal ions, and its optimization via
experimental design methodology. Microchimica Acta, 2013. 180, pp.1073-1084.
.Lan H, Gan N, Pan D, Hu F, Li T, Long N, Shen H, Feng Y. Development of a novel
magnetic molecularly imprinted polymer coating using porous zeolite imidazolate
framework-8 coated magnetic iron oxide as carrier for automated solid phase
microextraction of estrogens in fish and pork samples. Journal of Chromatography A.
;1365:35-44.
.Sohrabi MR, Matbouie Z, Asgharinezhad AA, Dehghani A. Solid phase extraction of
Cd(II) and Pb(II) using a magnetic metal-organic framework, and their
determination by FAAS. Microchimica Acta. 2013;180(7–8):589–97.
.Xia L, Liu L, Lv X, Qu F, Li G, You J. Towards the determination of sulfonamides in
meat samples: A magnetic and mesoporous metal-organic framework as an efficient
sorbent for magnetic solid phase extraction combined with high-performance liquid
chromatography. Journal of Chromatography A. 2017;1500:24-31.
.Li Z, Qi M, Tu C, Wang W, Chen J, Wang AJ. Magnetic Metal-Organic
Framework/Graphene Oxide-Based Solid-Phase Extraction Combined with
Spectrofluorimetry for the Determination of Enrofloxacin in Milk Sample. Food Anal
Methods. 2017;10(12):4094–103.
.Su H, Lin Y, Wang Z, Wong YLE, Chen X, Chan TWD. Magnetic metal–organic
framework–titanium dioxide nanocomposite as adsorbent in the magnetic solidphase
extraction of fungicides from environmental water samples. Journal of
Chromatography A. 2016;1466:21–8.
.Zhou Q, Lei M, Li J, Liu Y, Zhao K, Zhao D. Magnetic solid phase extraction of N- and
S-containing polycyclic aromatic hydrocarbons at ppb levels by using a zerovalent
iron nanoscale material modified with a metal organic framework of type Fe@MOF-
, and their determination by HPLC. Microchimica Acta. 2017;184(4):1029–36.
.Chen X, Ding N, Zang H, Yeung H, Zhao RS, Cheng C, dkk. Fe3O4@MOF core–shell
magnetic microspheres for magnetic solid-phase extraction of polychlorinated
biphenyls from environmental water samples. Journal of Chromatography A.
;1304:241–5.
.Liu Y, Gao Z, Wu R, Wang Z, Chen X, Chan TWD. Magnetic porous carbon derived
from a bimetallic metal–organic framework for magnetic solid-phase extraction of
organochlorine pesticides from drinking and environmental water samples. Journal
of Chromatography A. 2017;1479:55–61.
.Liang L, Wang X, Sun Y, Ma P, Li X, Piao H, dkk. Magnetic solid-phase extraction of
triazine herbicides from rice using metal-organic framework MIL-101(Cr)
functionalized magnetic particles. Talanta. 2018;179:512–9.
.Hassanpour A, Hosseinzadeh-Khanmiri R, Babazadeh M, Abolhasani J, Ghorbani-
Kalhor E. Determination of heavy metal ions in vegetable samples using a magnetic
metal–organic framework nanocomposite sorbent. Food Additives & Contaminants:
Part A. 2015 ;32(5):725-36.
.Wang Y, Chen H, Tang J, Ye G, Ge H, Hu X. Preparation of magnetic metal organic
frameworks adsorbent modified with mercapto groups for the extraction and
analysis of lead in food samples by flame atomic absorption spectrometry. Food
Chemistry. 2015 ;181:191-7.
.Rocío-Bautista P, Pino V, Ayala JH, Pasán J, Ruiz-Pérez C, Afonso AM. A magneticbased
dispersive micro-solid-phase extraction method using the metal-organic
framework HKUST-1 and ultra-high-performance liquid chromatography with
fluorescence detection for determining polycyclic aromatic hydrocarbons in waters
and fruit tea infusions. Journal of Chromatography A. 2016;1436:42–50.
.Ghorbani-Kalhor E, Hosseinzadeh-Khanmiri R, Babazadeh M, Abolhasani J,
Hassanpour A. Synthesis and application of a novel magnetic metal-organic
framework nanocomposite for determination of Cd, Pb, and Zn in baby food samples.
Canadian Journal of Chemistry. 2015;93(5):518-25..
.Ma J, Yao Z, Hou L, Lu W, Yang Q, Li J, dkk. Metal organic frameworks (MOFs) for
magnetic solid-phase extraction of pyrazole/pyrrole pesticides in environmental
water samples followed by HPLC-DAD determination. Talanta. 2016;161:686–92.
.Lu N, He X, Wang T, Liu S, Hou X. Magnetic solid-phase extraction using MIL-
(Cr)-based composite combined with dispersive liquid-liquid microextraction
based on solidification of a floating organic droplet for the determination of
pyrethroids in environmental water and tea samples. Microchemical Journal.
;137:449–55.
.Hao L, Wang C, Wu Q, Li Z, Zang X, Wang Z. Metal–organic framework derived
magnetic nanoporous carbon: novel adsorbent for magnetic solid-phase extraction.
Analytical chemistry. 2014;86(24):12199-205.