Main Article Content
Abstract
The aim of this study was to determine the anticholesterol activity of the stem extract of Uncaria cordata (Lour.) Merr. on total cholesterol levels in male mice (Mus musculus). Before carrying out the anticholesterol activity test, phytochemical tests were carried out to determine the content of secondary metabolites in Uncaria cordata stems. Furthermore, the anticholesterol activity test was carried out in vivo using male mice, male mice were induced by high-fat diet (PTL) in the form of beef brain, quail egg yolk and propylthiouracil to increase cholesterol levels in mice until they experienced hypercholesterolemia, then mice were induced by plant extracts to see anticholesterol activity. Cholesterol levels were measured using a glucometer (Autocheck). Phytochemical test results showed the content of secondary metabolites in the form of flavonoids, saponins, alkaloids, tannins and terpenoids. The results of the anti-cholesterol activity test showed that there was anti-cholesterol activity as indicated by a decrease in cholesterol levels in mice with hypercholesterolemia. A decrease of 11.45% at a dose of 5.3 mg/30grW; 12.89% at a dose of 10.2mg/30grW and 21.05% at a dose of 21.2mg/30grW.
Key words : Anticholesterol, Uncaria cordata (Lour.) Merr., Hypercholesterolemia
Article Details
Copyright (c) 2023 Rika Indriyani, Dewi Handayani, Nurhamidah Nurhamidah, Agus Sundaryono
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree with the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.