Article Sidebar

Download
PDF
Statistic
Read Counter : 210 Download : 324

Downloads

Download data is not yet available.

Main Article Content

Abstract

One of Bengkulu's local culture is the utilization of medicinal plants by the people of Bengkulu, especially South Bengkulu, namely "Simbagh Utak" (Hydnophytum formicarum) for treating various diseases including Gout. However, they still use naturally, there is no scientific studied. This study was aimed to analyze the effect of “Simbagh Utak” (H. formicarum) on the reduction of serum uric acid levels in hyperuricemia male mice. This study used 25 male mice, that devided into 5 groups. The control group was given pellet feed (G1). We injected the high purine feed treatment per-oral to induce hyperuricemia (Negative control, G2) and then given H. formicarum extract 5.3mg/30gW (G3), 10.2mg/30gW (G4) and 21,2mg/30gW (G5). Uric acid measurements were performed using a digital method with easy touch /GCU. The tubers were extracted with maceration, eluent selection and isolation of the isolated components was carried out using thin layer chromatography and column chromatography. The extraction results were analyzed of functional groups using FTIR. The result showed that “simbagh utak” extract 5.3mg/30gW, 10.2mg/30gW and 21,2mg/30gW could reduced uric acid levels of hyperuricemia male mice 34.1%, 48.0% dan 53.4% respectively. On this basis, we conclude that "Simbagh Utak" extract could reduced levels of uric acid M. musculus males who have experienced a state of hyperuricemia (excess uric acid) very significantly at a dose of 21.2mg /30gW.

Article Details

License

The journal allows the author(s) to hold the copyright without restrictions.


Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

How to Cite
Ernis, G., Handayani, D., & Sundaryono, A. (2020). Dampak Pemberian Ekstrak “Simbagh Utak” (Hydnophytum formicarum) Terhadap Penurunan Kadar Asam Urat Darah pada Mencit (Mus musculus) Jantan Hiperurisemia. PENDIPA Journal of Science Education, 4(2), 94–100. https://doi.org/10.33369/pendipa.4.2.94-100
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Andriani, Y., Mohamad, H., Kassim, M.N.I., Rosnan, N.D., Syamsumir, D.F., Saidin, J., Muhammad, T.S.T., Amir, H. (2017) Evaluation on H. formicarum Tuber from Setiu Wetland (Malaysia) and Muara Rupit (Indonesia) for Antibacterial and Antioxidant activities, and anti-cancer Potency against MCF-7 and HeLa Cells, Journal of Applied Pharmaceutical Science, 7(09):030-037.
  2. Arian, P., Sundaryono, A. Ginting, A.M. (2013), Undergraduated thesis, Universitas Bengkulu.
  3. Bustanussalam (2010) Penentuan struktur molekul dari fraksi air tumbuhan “sarang semut” Myrmecodia pendens Merr & Perry yang mempunyai aktivitas sitotoksik dan antioksidan, Graduated thesis, Institut Pertanian Bogor.
  4. Dewanti, S. (2010) Kolesterol, Diabetes, dan Asam Urat. Jawa Tengah: Kawan Kita.
  5. Haryani, Eni. (2007) Pemisahan Komponen Rimpang Temu Kunci secara Kromatografi Kolom. Teknik pertanian, 12 (1).
  6. Hille R. (2006) Structure and Function of Xanthine Oxidoreductase, European Journal of Inorganic Chemistry, (10), 1905–2095.
  7. Jeli, M dan Makiyah, N. (2011) Pengaruh Pemberian Infusa Tumbuhan Sarang semut (H. formicarum) Terhadap Gambaran Histologi Pankreas Pada Tikus (Rattus norvegicus) Diabetes Terinduksi Aloksan. Jurnal Kesehatan Pharmamedika, 3(1) .
  8. Nasrul, E., Sofitri (2012) Hiperurisemia pada Pra Diabetes, Jurnal Kesehatan Andalas, 1(2).
  9. Purnamasari M., Ruyani, A., Sundaryono, A. (2013) Pengaruh ekstrak umbi “Simbagh utak” (H. formicarum.) terhadap kadar gula darah Mus musculus jantan diinduksi aloksan dan karakterisasi hasil isolasi menggunakan 1H-NMR, Undergraduated thesis, Universitas Bengkulu.
  10. Safniyeti, Sulistijorini, & Chikmawati, T. (2018) Species Richness and Habitat Suitability of Myrmecophytes in Bengkulu: Host Tree, Coexist Epiphytes and Animals. Biosaintifika: Journal of Biology & Biology Education, 10(1), 183-190.
  11. Sari, E.N., Sundaryono, A., Handayani, D. (2016) Biosintesis Nanopartikel Perak - Ekstrak Umbi “Simbagh Utak” Dengan Metode Reduksi Dan Pengaruhnya Terhadap Penurunan Kadar Kolesterol Mus Musculus Jantan. Undergraduated thesis, Universitas Bengkulu.
  12. Simanjuntak, Fanny, Subroto. (2010) Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang semut (Myrmecodia pendens Merr.& Perry) sebagai Penghambat Xantin oksidase, Jurnal Ilmu Kefarmasian Indonesia, 8(1), 49-54.
  13. Subroto, M.A. dan H. Saputro. (2006) Gempur Penyakit dengan Sarang semut, Jakarta: Penebar Swadaya.
  14. Sukmono, R. (2009) Mengatasi Aneka Penyakit dengan Terapi Herbal, Jakarta: Agromedia Pustaka.
  15. Wulandari, R., Sundaryono, A., Handayani, D. (2016) Pengaruh Nanopartikel Kitosan-Ekstrak Umbi Simbagh Utak (H. formicarum) Terhadap Peningkatan Aktivitas Antimalaria Pada Mencit Jantan Yang Terinfeksi Plasmodium Berghei. Undergraduated thesis, Universitas Bengkulu.