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May 31, 2024
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Abstract
Buni is a plant that is widespread in Asia, especially Indonesia. Buni fruit has been reported to contain anthocyanins which have activity as flavonoids, antiocyanins, saponins, alkaloids and as high antioxidant agents, but because Buni fruit is seasonal so raw materials depend on the season, therefore to increase availability it needs to be extracted and formulated in a form preparations. The purpose of this study was to obtain an instant granule formula that meets the physical characteristics and to determine the IC50 value of the antioxidant activity of the instant granule preparation of buni fruit extract (Antidesma bunius L.). The extract was prepared by extraction method using 70% ethanol solvent with the addition of 3% citric acid for 3x24 hours. Instant granules were prepared using the wet granulation method using varying concentrations of PVP as a binder, namely 1%, 3% and 5%. Furthermore, the physical characteristics were evaluated including flow properties, moisture content, soluble time, then antioxidant activity was determined based on the IC50 value using the DPPH method. The results showed that F1 and F2 had good flow properties and F3 had very good flow properties, the moisture content was around 2-4% and the dissolution time was 2-3 minutes. Based on the test results obtained formula 3 with a PVP concentration of 5% is a formula that meets the physical requirements of granules and an IC50 value of 65.94 µg/mL is included in the strong antioxidant category.
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Copyright (c) 2024 Nur Khairi, Amriani Sapra, Suryani Tawali, Maulita Indrisari
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How to Cite
Jalil Genisa, N. K., Amriani Sapra, Suryani Tawali, & Maulita Indrisari. (2024). INSTANT GRANULATION FORMULATION OF BUNI FRUIT EXTRACT (Antidesma bunius L.) AS AN ANTIOXIDANT DRINK . Jurnal Agroindustri, 14(1), 1–10. https://doi.org/10.31186/jagroindustri.14.1.1-10
References
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Aksornchu, P., Chamnansilpa, N., Adisakwattana, S., Thilavech, T., Choosak, C., Marnpae, M., Makynen, K., Dahlan, W., and Ngamukote, Sathaporn. (2020). Inhibitory Effect of Antidesma bunius Fruit Extract on Carbohydrate Digestive Enzymes Activity and Protein Glycation In Vitro. Antioxidants (Basel, Switzerland), 10(1), 1-18. Available at: https://doi.org/10.339 0/antiox10010032.
Akther, S., A., Alim, M., R., Badsha, M., A., Matin, M., Ahmad, and Z., Hoque S. M.. (2020). Formulation and quality evaluation of instant mango drink powder. Food Research. 4(4), 1287–1296. Available at: https://doi.org/10.266 56/FR.2017.4(4).077.
Amalia, F. and Afnani, Galih Nur. (2013). Extraction and Stability Test of Anthocyanin from Buni Fruits (Antidesma Bunius L) as an Alternative Natural and Safe Food Colorants. J. Food Pharm.Sci. Available at: www.jfoodpharmsci .com.
Dipahayu, D., Rachmawati, F. N. & Safitri, D. (2022). Formulasi Granul Instan Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3. Jurnal Sains dan Kesehatan, 4(SE-1), 88–92. Available at: https://doi.org/10.250 26/jsk.v4iSE-1.1693.
Djarot, P. & Badar, M. (2017). Formulation and Production of Granule from Annona muricate Juice as Antihypertensive Instant Drink. International Journal of Pharmacy and Pharmaceutical Sciences, 9(5), 18-22. Available at: https://doi.org/10.22159/ijpps.2017v9i5.16506.
Eka Puspita, O., Ebtavanny, T. G. & Fortunata, F. A. (2015). Studi Pengaruh Jenis Bahan Pengikat Sediaan Tablet Dispersi Solid Kunyit Terhadap Profil Disolusi Ekstrak Kunyit (Curcuma domestica). Pharmaceutical Journal of Indonesia. Available at: http://.pji.ub.ac.id.
Elisabeth, V., Yamlean, P. V. Y. & Supriati, H. S. (2018). Formulasi Sediaan Granul dengan Bahan Pengikat Pati Kulit Pisang Goroho (Musa acuminafe L.) dan Pengaruhnya pada Sifat Fisik Granul, PHARMACON Jurnal Ilmiah Farmasi-UNSRAT.
Fadhila, N., Sriwidodo, S. & Chaerunisaa, A.. (2022). Instant Granules of Mangosteen Peel (Garcinia Mangostana L.) Ethanol Extract as Antioxidants. Sciences of Pharmacy, 1(1), 1–7. Available at: https://doi.org/10.58920/sciphar01010001.
Juhadi, W. & Muzi Marpaung, A.. (2021). Optimization of Time, Temperature, and pH for the Extraction of Anthocyanin from Buni (Antidesma bunius) Fruit. Food Science and Technology Journal (Foodscitech), 8–15. Available at: https://doi.org/10. 25139/fst.v4i1.3319.
Hamka, Zulfahmi. (2020). Skrining Antioksidan Ekstrak Buah Buni (Antidesma bunius (L) Spreng.) asal Kabupaten Enrekang dengan Metode Peredaman Radikal DPPH. Jurnal, journal.yamasi.ac.id
Maulida, V. S. & Adi, A. C. (2018). Daya Terima dan Kandungan Flavonoid Sirup Kombinasi Belimbing Wuluh (Averrhoa bilimbi L) dan Daun Tin (Ficus carica L) sebagai Minimum Alternatif Antioksidan Kaya Flavonid. Media Gizi Indonesia, 13(2), p. 159. Available at: https://doi.org/10.20473/mgi.v13i2.159-167.
Mayefis, D. & Bidriah, M. (2020). Formulasi Sediaan Tablet Effervescent Ekstrak Herbal Meniran (Phyllantus niruri L) dengan Variasi Konsentrasi Sumber Asam dan Basa. ORIGINALARTICLE. Available at: http://journal.ahmareduc.or.id/index.php/AMHJ.
Murini, T., Wahyuningsih, M. S. H., Fudholi, A., & Satoto, T. B. T.. (2020). Optimization of Formula Granule of Lempuyang Gajah (Zingiber zerumbet (L) J.E.Smith) Rhizome Purified Extract as a Larvicide. Majalah Obat Tradisional, 25(1), 34-41. Available at: https://doi.org/10.2 2146/mot.48754
Pamungkas, A., Sulaeman, A., & Roosita, K.. (2014). Pengembangan Produk Minuman Jeli Ekstrak Daun Hantap (Sterculia oblongata R. Brown) sebagai Alternatif Pangan Fungsional. J. Gizi Pangan, 9(3), 195–202.
Rahman, A., Malik, A. & Ahmad, R. (2015). Skrining Fitokima dan Uji Antioksidan Ekstrak Etanolik Buah Buni (Antidesma bunius (L.) SPRENG). Jurnal Fitofarmaka Indonesia.
Saavedra, Leos, Z., Porras, C. L., Diaz, S. B. A., Teran, A. T., & Enriquez, A. J. B.. (2015). Technological Application of Maltodextrins According to the Degree of Polymerization. Molecules (Basel, Switzerland), 20(12), 21067–21081. Available at: https://doi.org/10.3390/molecules201219746.
Suhartatik, N., Karyantina, M., Mustofa, A., Cahyanto, M. N., Raharjo, S., & Rahayu, E. S.. (2013). Stabilitas Ekstrak Antosianin Beras Ketan (Oryza sativa var. glutinosa) Hitam selama Proses Pemanasan dan Penyimpanan, AGRITECH, 33(4), 384-390. Available at : https://jurnal.ugm.ac.id/agritech/article/view/9533/7108
Supomo, Bella, D. R. & Sa’adah. (2015). Formulasi Granul Ekstak Kulit Buah Manggis (Garcinia manostana L) menggunakan Areosil dan Avicel pH 101. J. Trop. Pharm. Chem. 2015, 3(2) 131-137.
References
Aksornchu, P., Chamnansilpa, N., Adisakwattana, S., Thilavech, T., Choosak, C., Marnpae, M., Makynen, K., Dahlan, W., and Ngamukote, Sathaporn. (2020). Inhibitory Effect of Antidesma bunius Fruit Extract on Carbohydrate Digestive Enzymes Activity and Protein Glycation In Vitro. Antioxidants (Basel, Switzerland), 10(1), 1-18. Available at: https://doi.org/10.339 0/antiox10010032.
Akther, S., A., Alim, M., R., Badsha, M., A., Matin, M., Ahmad, and Z., Hoque S. M.. (2020). Formulation and quality evaluation of instant mango drink powder. Food Research. 4(4), 1287–1296. Available at: https://doi.org/10.266 56/FR.2017.4(4).077.
Amalia, F. and Afnani, Galih Nur. (2013). Extraction and Stability Test of Anthocyanin from Buni Fruits (Antidesma Bunius L) as an Alternative Natural and Safe Food Colorants. J. Food Pharm.Sci. Available at: www.jfoodpharmsci .com.
Dipahayu, D., Rachmawati, F. N. & Safitri, D. (2022). Formulasi Granul Instan Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3. Jurnal Sains dan Kesehatan, 4(SE-1), 88–92. Available at: https://doi.org/10.250 26/jsk.v4iSE-1.1693.
Djarot, P. & Badar, M. (2017). Formulation and Production of Granule from Annona muricate Juice as Antihypertensive Instant Drink. International Journal of Pharmacy and Pharmaceutical Sciences, 9(5), 18-22. Available at: https://doi.org/10.22159/ijpps.2017v9i5.16506.
Eka Puspita, O., Ebtavanny, T. G. & Fortunata, F. A. (2015). Studi Pengaruh Jenis Bahan Pengikat Sediaan Tablet Dispersi Solid Kunyit Terhadap Profil Disolusi Ekstrak Kunyit (Curcuma domestica). Pharmaceutical Journal of Indonesia. Available at: http://.pji.ub.ac.id.
Elisabeth, V., Yamlean, P. V. Y. & Supriati, H. S. (2018). Formulasi Sediaan Granul dengan Bahan Pengikat Pati Kulit Pisang Goroho (Musa acuminafe L.) dan Pengaruhnya pada Sifat Fisik Granul, PHARMACON Jurnal Ilmiah Farmasi-UNSRAT.
Fadhila, N., Sriwidodo, S. & Chaerunisaa, A.. (2022). Instant Granules of Mangosteen Peel (Garcinia Mangostana L.) Ethanol Extract as Antioxidants. Sciences of Pharmacy, 1(1), 1–7. Available at: https://doi.org/10.58920/sciphar01010001.
Juhadi, W. & Muzi Marpaung, A.. (2021). Optimization of Time, Temperature, and pH for the Extraction of Anthocyanin from Buni (Antidesma bunius) Fruit. Food Science and Technology Journal (Foodscitech), 8–15. Available at: https://doi.org/10. 25139/fst.v4i1.3319.
Hamka, Zulfahmi. (2020). Skrining Antioksidan Ekstrak Buah Buni (Antidesma bunius (L) Spreng.) asal Kabupaten Enrekang dengan Metode Peredaman Radikal DPPH. Jurnal, journal.yamasi.ac.id
Maulida, V. S. & Adi, A. C. (2018). Daya Terima dan Kandungan Flavonoid Sirup Kombinasi Belimbing Wuluh (Averrhoa bilimbi L) dan Daun Tin (Ficus carica L) sebagai Minimum Alternatif Antioksidan Kaya Flavonid. Media Gizi Indonesia, 13(2), p. 159. Available at: https://doi.org/10.20473/mgi.v13i2.159-167.
Mayefis, D. & Bidriah, M. (2020). Formulasi Sediaan Tablet Effervescent Ekstrak Herbal Meniran (Phyllantus niruri L) dengan Variasi Konsentrasi Sumber Asam dan Basa. ORIGINALARTICLE. Available at: http://journal.ahmareduc.or.id/index.php/AMHJ.
Murini, T., Wahyuningsih, M. S. H., Fudholi, A., & Satoto, T. B. T.. (2020). Optimization of Formula Granule of Lempuyang Gajah (Zingiber zerumbet (L) J.E.Smith) Rhizome Purified Extract as a Larvicide. Majalah Obat Tradisional, 25(1), 34-41. Available at: https://doi.org/10.2 2146/mot.48754
Pamungkas, A., Sulaeman, A., & Roosita, K.. (2014). Pengembangan Produk Minuman Jeli Ekstrak Daun Hantap (Sterculia oblongata R. Brown) sebagai Alternatif Pangan Fungsional. J. Gizi Pangan, 9(3), 195–202.
Rahman, A., Malik, A. & Ahmad, R. (2015). Skrining Fitokima dan Uji Antioksidan Ekstrak Etanolik Buah Buni (Antidesma bunius (L.) SPRENG). Jurnal Fitofarmaka Indonesia.
Saavedra, Leos, Z., Porras, C. L., Diaz, S. B. A., Teran, A. T., & Enriquez, A. J. B.. (2015). Technological Application of Maltodextrins According to the Degree of Polymerization. Molecules (Basel, Switzerland), 20(12), 21067–21081. Available at: https://doi.org/10.3390/molecules201219746.
Suhartatik, N., Karyantina, M., Mustofa, A., Cahyanto, M. N., Raharjo, S., & Rahayu, E. S.. (2013). Stabilitas Ekstrak Antosianin Beras Ketan (Oryza sativa var. glutinosa) Hitam selama Proses Pemanasan dan Penyimpanan, AGRITECH, 33(4), 384-390. Available at : https://jurnal.ugm.ac.id/agritech/article/view/9533/7108
Supomo, Bella, D. R. & Sa’adah. (2015). Formulasi Granul Ekstak Kulit Buah Manggis (Garcinia manostana L) menggunakan Areosil dan Avicel pH 101. J. Trop. Pharm. Chem. 2015, 3(2) 131-137.
Akther, S., A., Alim, M., R., Badsha, M., A., Matin, M., Ahmad, and Z., Hoque S. M.. (2020). Formulation and quality evaluation of instant mango drink powder. Food Research. 4(4), 1287–1296. Available at: https://doi.org/10.266 56/FR.2017.4(4).077.
Amalia, F. and Afnani, Galih Nur. (2013). Extraction and Stability Test of Anthocyanin from Buni Fruits (Antidesma Bunius L) as an Alternative Natural and Safe Food Colorants. J. Food Pharm.Sci. Available at: www.jfoodpharmsci .com.
Dipahayu, D., Rachmawati, F. N. & Safitri, D. (2022). Formulasi Granul Instan Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3. Jurnal Sains dan Kesehatan, 4(SE-1), 88–92. Available at: https://doi.org/10.250 26/jsk.v4iSE-1.1693.
Djarot, P. & Badar, M. (2017). Formulation and Production of Granule from Annona muricate Juice as Antihypertensive Instant Drink. International Journal of Pharmacy and Pharmaceutical Sciences, 9(5), 18-22. Available at: https://doi.org/10.22159/ijpps.2017v9i5.16506.
Eka Puspita, O., Ebtavanny, T. G. & Fortunata, F. A. (2015). Studi Pengaruh Jenis Bahan Pengikat Sediaan Tablet Dispersi Solid Kunyit Terhadap Profil Disolusi Ekstrak Kunyit (Curcuma domestica). Pharmaceutical Journal of Indonesia. Available at: http://.pji.ub.ac.id.
Elisabeth, V., Yamlean, P. V. Y. & Supriati, H. S. (2018). Formulasi Sediaan Granul dengan Bahan Pengikat Pati Kulit Pisang Goroho (Musa acuminafe L.) dan Pengaruhnya pada Sifat Fisik Granul, PHARMACON Jurnal Ilmiah Farmasi-UNSRAT.
Fadhila, N., Sriwidodo, S. & Chaerunisaa, A.. (2022). Instant Granules of Mangosteen Peel (Garcinia Mangostana L.) Ethanol Extract as Antioxidants. Sciences of Pharmacy, 1(1), 1–7. Available at: https://doi.org/10.58920/sciphar01010001.
Juhadi, W. & Muzi Marpaung, A.. (2021). Optimization of Time, Temperature, and pH for the Extraction of Anthocyanin from Buni (Antidesma bunius) Fruit. Food Science and Technology Journal (Foodscitech), 8–15. Available at: https://doi.org/10. 25139/fst.v4i1.3319.
Hamka, Zulfahmi. (2020). Skrining Antioksidan Ekstrak Buah Buni (Antidesma bunius (L) Spreng.) asal Kabupaten Enrekang dengan Metode Peredaman Radikal DPPH. Jurnal, journal.yamasi.ac.id
Maulida, V. S. & Adi, A. C. (2018). Daya Terima dan Kandungan Flavonoid Sirup Kombinasi Belimbing Wuluh (Averrhoa bilimbi L) dan Daun Tin (Ficus carica L) sebagai Minimum Alternatif Antioksidan Kaya Flavonid. Media Gizi Indonesia, 13(2), p. 159. Available at: https://doi.org/10.20473/mgi.v13i2.159-167.
Mayefis, D. & Bidriah, M. (2020). Formulasi Sediaan Tablet Effervescent Ekstrak Herbal Meniran (Phyllantus niruri L) dengan Variasi Konsentrasi Sumber Asam dan Basa. ORIGINALARTICLE. Available at: http://journal.ahmareduc.or.id/index.php/AMHJ.
Murini, T., Wahyuningsih, M. S. H., Fudholi, A., & Satoto, T. B. T.. (2020). Optimization of Formula Granule of Lempuyang Gajah (Zingiber zerumbet (L) J.E.Smith) Rhizome Purified Extract as a Larvicide. Majalah Obat Tradisional, 25(1), 34-41. Available at: https://doi.org/10.2 2146/mot.48754
Pamungkas, A., Sulaeman, A., & Roosita, K.. (2014). Pengembangan Produk Minuman Jeli Ekstrak Daun Hantap (Sterculia oblongata R. Brown) sebagai Alternatif Pangan Fungsional. J. Gizi Pangan, 9(3), 195–202.
Rahman, A., Malik, A. & Ahmad, R. (2015). Skrining Fitokima dan Uji Antioksidan Ekstrak Etanolik Buah Buni (Antidesma bunius (L.) SPRENG). Jurnal Fitofarmaka Indonesia.
Saavedra, Leos, Z., Porras, C. L., Diaz, S. B. A., Teran, A. T., & Enriquez, A. J. B.. (2015). Technological Application of Maltodextrins According to the Degree of Polymerization. Molecules (Basel, Switzerland), 20(12), 21067–21081. Available at: https://doi.org/10.3390/molecules201219746.
Suhartatik, N., Karyantina, M., Mustofa, A., Cahyanto, M. N., Raharjo, S., & Rahayu, E. S.. (2013). Stabilitas Ekstrak Antosianin Beras Ketan (Oryza sativa var. glutinosa) Hitam selama Proses Pemanasan dan Penyimpanan, AGRITECH, 33(4), 384-390. Available at : https://jurnal.ugm.ac.id/agritech/article/view/9533/7108
Supomo, Bella, D. R. & Sa’adah. (2015). Formulasi Granul Ekstak Kulit Buah Manggis (Garcinia manostana L) menggunakan Areosil dan Avicel pH 101. J. Trop. Pharm. Chem. 2015, 3(2) 131-137.