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Abstract
Diabetes Mellitus (DM) is the most common of the endocrine disorder and chronic hyperglycaemia due to relative or absolute lack of insulin. The aim of the study is to investigate the the body weight profile, decreased of body weight (%) and glucose level of the bitter melon juice and boiled extract dietin alloxan induced diabetic rats. Therats were divided randomly into three groups with fed AIN-93, the first group is control with water diet only, whereas the second group was given bitter melon juice extract diet, and third group with bitter melon boiled extract diet. The diet of bitter melon juice and boiled extract were done by oral administration of 2ml/200 g body weight of rats for 8 days. The result showed that diet with bitter melon juice and boiled extract could improve body weight after 4 days. Additionally, the decreased of body weight percentage afterbitter melon juice (2.68%) and boiled extract (1.89%) diet were effective than control (8.81%). Bitter melon juice extract may effective in reduced blood glucose levels than bitter melon boiled extract and control. The research indicate that bitter melon acts recovery body weight and regulating blood glucose level on diabetic rats.
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References
- Ahmed, I., Adeghate, E., Sharma, A.K., Pallot, D.J., and Singh, J. 1998. Effects of Momordica charantia Fruit Jus on Islet Morphology in The Pancreas of Streptozotocin- Diabetic Rats. Diabetes Research and Clinical Practice, 40. Hal. 145 - 151.
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- Anonim. 2011. Bitter Melon. http://en.wikipedia.org/wiki/Bitter_melon [diakses pada tanggal 1 Januari 2011].
- Cummings, E., dan Hundal, H.S., Wackerhage, H., Hope, M., Belle, M., Adeghate, E. dan Singh, J. 2004. Momordica charantia Fruit Juice Stimulates Glucose and Amino Acid Uptakes in L6 Myotubes. Moleculer and Celluler Biochemistry, 261. Hal. 99 - 104.
- El-Baky, A.A., Abdullah, A., El-Mawgoud, H.A., dan El-Hay, E. A. 2009. Hypoglycemic and Hypolipidaemic Action of Bitter Melon on Normoglycemic and Hyperglycemic Diabetes Rats. Research Journal of Medicine and Medical Sciences, Vol. 4 (2). Hal. 519 - 525.
- Raman, A., dan Lau, C. 1996. Anti Diabetic Properties and Phyto-chemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine, 2. Hal. 349 - 362
- Grover, J.K. dan Yadav, S. P. 2004. Pharmacological Actions and Potential Uses of Momordica charantia : a review. J. Ethno-pharmacol, 93. Hal. 123 - 132
- Kubota, J., dan Siriamornpun, S. 2008. Phenolic Contents and Antioxidant Activities of Bitter Gourd (Momordica charantia L.) Leaf, Stem and Fruit Fraction Extracts in Vitro. Food Chemistry, 110. Hal. 881 - 890
- Kurnia, Y., Afifah, N., Mustofa, A., dan Firdausy, U. 2010. Pengaruh Pemberian Rebusan Daun Pare (Momordica charantia L.) terhadap Kadar Kolesterol Total Serum Da-rah Tikus Putih (Rattus norvegicus) dengan Induksi Hiperkoles-terolemia. http://aila.blog.uns.ac.id/2010/04/1/ [diakses pada tanggal 26 Desember 2010].
- Lola, M. H. C., Liben, P., dan Soemartojo, J. 2008. Efek Kombinasi Jus Da-ging Buah Pare (Momordica charantia L.) dan Jus Umbi Ba-wang Putih (Allium sativum L.) terhadap Penurunan Kadar Glukosa Darah. Jurnal Obat Bahan Alam, Vol. 7(1). Hal. 28 - 33
- Shetty, A.K., Kumar, G.S., Sambaiah, K., and Salimath, P.V. 2005. Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetes Rats. Plant Foods for Human Nutrition 60. Hal. 109 - 112.
- Sidartawan, S. 2006. Jumlah Diabetes Mellitus. http://www.medicastore.com. [diakses pada tanggal 28 Desember 2010].
- Sundari, D., Padmawinata, Ruslan K. 1996. Analisis Fitokimia Ekstrak Etanol Daging Buah Pare (Momordica charantia L.). http://bahan-alam.fa.itb.ac.id/detail.php?id=132 [diakses pada tanggal 1 Januari 2011].
- Tarigan, I. 2009. Herbal-herbal Ampuh Pengusir Diabetes. http://www.mediaindonesia.com/media. [diakses pada tanggal 28 Desember 2010].
- Zaif. 2009. Pemanfaatan Pare (Momordica charantia L.) sebagai Obat Alter-natif Diabetes Melitus. http://zaifbio.wordpress.com/2009/02/18/pemanfaatan-pare [diakses pada tanggal 6 Januari 2011].
References
Ahmed, I., Adeghate, E., Sharma, A.K., Pallot, D.J., and Singh, J. 1998. Effects of Momordica charantia Fruit Jus on Islet Morphology in The Pancreas of Streptozotocin- Diabetic Rats. Diabetes Research and Clinical Practice, 40. Hal. 145 - 151.
Anonim. 2010. Tiga Obat Alami untuk Diabetes. http://majalahkesehatan.com/3-obat-alami-untuk-diabetes/ [diakses pada tanggal 3 Desember 2010].
Anonim. 2011. Bitter Melon. http://en.wikipedia.org/wiki/Bitter_melon [diakses pada tanggal 1 Januari 2011].
Cummings, E., dan Hundal, H.S., Wackerhage, H., Hope, M., Belle, M., Adeghate, E. dan Singh, J. 2004. Momordica charantia Fruit Juice Stimulates Glucose and Amino Acid Uptakes in L6 Myotubes. Moleculer and Celluler Biochemistry, 261. Hal. 99 - 104.
El-Baky, A.A., Abdullah, A., El-Mawgoud, H.A., dan El-Hay, E. A. 2009. Hypoglycemic and Hypolipidaemic Action of Bitter Melon on Normoglycemic and Hyperglycemic Diabetes Rats. Research Journal of Medicine and Medical Sciences, Vol. 4 (2). Hal. 519 - 525.
Raman, A., dan Lau, C. 1996. Anti Diabetic Properties and Phyto-chemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine, 2. Hal. 349 - 362
Grover, J.K. dan Yadav, S. P. 2004. Pharmacological Actions and Potential Uses of Momordica charantia : a review. J. Ethno-pharmacol, 93. Hal. 123 - 132
Kubota, J., dan Siriamornpun, S. 2008. Phenolic Contents and Antioxidant Activities of Bitter Gourd (Momordica charantia L.) Leaf, Stem and Fruit Fraction Extracts in Vitro. Food Chemistry, 110. Hal. 881 - 890
Kurnia, Y., Afifah, N., Mustofa, A., dan Firdausy, U. 2010. Pengaruh Pemberian Rebusan Daun Pare (Momordica charantia L.) terhadap Kadar Kolesterol Total Serum Da-rah Tikus Putih (Rattus norvegicus) dengan Induksi Hiperkoles-terolemia. http://aila.blog.uns.ac.id/2010/04/1/ [diakses pada tanggal 26 Desember 2010].
Lola, M. H. C., Liben, P., dan Soemartojo, J. 2008. Efek Kombinasi Jus Da-ging Buah Pare (Momordica charantia L.) dan Jus Umbi Ba-wang Putih (Allium sativum L.) terhadap Penurunan Kadar Glukosa Darah. Jurnal Obat Bahan Alam, Vol. 7(1). Hal. 28 - 33
Shetty, A.K., Kumar, G.S., Sambaiah, K., and Salimath, P.V. 2005. Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetes Rats. Plant Foods for Human Nutrition 60. Hal. 109 - 112.
Sidartawan, S. 2006. Jumlah Diabetes Mellitus. http://www.medicastore.com. [diakses pada tanggal 28 Desember 2010].
Sundari, D., Padmawinata, Ruslan K. 1996. Analisis Fitokimia Ekstrak Etanol Daging Buah Pare (Momordica charantia L.). http://bahan-alam.fa.itb.ac.id/detail.php?id=132 [diakses pada tanggal 1 Januari 2011].
Tarigan, I. 2009. Herbal-herbal Ampuh Pengusir Diabetes. http://www.mediaindonesia.com/media. [diakses pada tanggal 28 Desember 2010].
Zaif. 2009. Pemanfaatan Pare (Momordica charantia L.) sebagai Obat Alter-natif Diabetes Melitus. http://zaifbio.wordpress.com/2009/02/18/pemanfaatan-pare [diakses pada tanggal 6 Januari 2011].